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Is afatinib a treatment option for brain metastases in patients with EGFR mutation-positive non-small cell lung cancer?

   
@article{ATM10573,
	author = {Satomi Watanabe and Hidetoshi Hayashi and Kazuhiko Nakagawa},
	title = {Is afatinib a treatment option for brain metastases in patients with EGFR mutation-positive non-small cell lung cancer?},
	journal = {Annals of Translational Medicine},
	volume = {4},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {Treatment for advanced non-small cell lung cancer (NSCLC) depends on the molecular characteristics of the tumor. Mutations of the gene for the epidermal growth factor receptor (EGFR) are present in ~32% of Asians and ~7% of individuals of other ethnic groups with NSCLC, with deletions in exon 19 and an L858R point mutation in exon 21 accounting for ~90% of such genetic alterations detected at diagnosis (1). NSCLC tumors that harbor EGFR mutations are oncogene addicted and therefore usually sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/10573}
}