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Management and postoperative outcome in primary lung cancer and heart disease co-morbidity: a systematic review and meta-analysis

  
@article{ATM10694,
	author = {George D. Bablekos and Antonis Analitis and Stylianos A. Michaelides and Konstantinos A. Charalabopoulos and Anastasia Tzonou},
	title = {Management and postoperative outcome in primary lung cancer and heart disease co-morbidity: a systematic review and meta-analysis},
	journal = {Annals of Translational Medicine},
	volume = {4},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {Background: Co-morbidity of primary lung cancer (LC) and heart disease (HD), both requiring surgical therapy, characterizes a high risk group of patients necessitating prompt diagnosis and treatment. The aim of this study is the review of available evidence guiding the management of these patients.		
Methods: Postoperative outcome of patients operated for primary LC (first meta-analysis) and for both primary LC and HD co-morbidity (second meta-analysis), were studied. Parameters examined in both meta-analyses were thirty-day postoperative mortality, postoperative complications, three- and five-year survival probabilities. The last 36 years were reviewed by using the PubMed data base. Thirty-seven studies were qualified for both meta-analyses.		
Results: The pooled 30-day mortality percentages (%) were 4.16% [95% confidence interval (CI): 2.68–5.95] (first meta-analysis) and 5.26% (95% CI: 3.47–7.62) (second meta-analysis). Higher percentages of squamous histology and lobectomy, were significantly associated with increased (P=0.001) and decreased (P},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/10694}
}