@article{ATM10827,
author = {Karn Wijarnpreecha and Charat Thongprayoon and Panadeekarn Panjawatanan and Patompong Ungprasert},
title = {Proton pump inhibitors and risk of dementia},
journal = {Annals of Translational Medicine},
volume = {4},
number = {12},
year = {2016},
keywords = {},
abstract = {Background: Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications. Recent studies have raised a concern over increased risk of dementia among PPIs users but the results of those studies were inconsistent. We conducted this systematic review and meta-analysis to summarize all available data.
Methods: A literature search was performed in MEDLINE and EMBASE database from inception to April 2016. Observational studies that reported risk of dementia among PPIs users compared with non-users were included. Point estimates were extracted from individual studies and pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using a random-effect, generic inverse variance method.
Results: Four studies were included in the analysis. Pooled RR of dementia among PPIs users compared with non-users was 1.08 (95% CI, 0.82–1.43). Sensitivity analysis including only cohort studies demonstrated a higher risk with pooled RR of 1.44 (95% CI, 1.36–1.52).
Conclusions: Our study demonstrated an increased risk of dementia among PPIs users. Whether this association is causal requires further investigations.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/10827}
}