@article{ATM11108,
author = {Zhongheng Zhang and Qian Li and Lingzhi Jiang and Bo Xie and Xiaowei Ji and Jiahong Lu and Ronglin Jiang and Shu Lei and Shihao Mao and Lijun Ying and Di Lu and Xiaoshui Si and Jianxin He and Mingxia Ji and Jianhua Zhu and Guodong Chen and Yadi Shao and Yinghe Xu and Ronghai Lin and Chao Zhang and Weiwen Zhang and Jian Luo and Tianzheng Lou and Xuwei He and Kun Chen and Renhua Sun},
title = {Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: a study protocol for before-and-after design},
journal = {Annals of Translational Medicine},
volume = {4},
number = {16},
year = {2016},
keywords = {},
abstract = {Introduction: Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed an enteral feeding protocol and planed a before-and-after comparative trial to explore whether implementation of enteral feeding protocol was able to improve clinical outcomes.
Methods and analysis: The study will be conducted in intensive care units (ICUs) of ten tertiary care academic centers. Critically ill patients expected to stay in ICU for over 3 days and require enteral nutrition (EN) were potentially eligible. This is a before-and-after study comprising three phases: The first phase is the period without enteral feeding protocol; the second phase involves four-week training program, and the last phase is to perform the protocol in participating centers. We plan to enroll a total of 350 patients to provide an 80% power and 0.05 error rate to detect a 15% reduction of mortality. The primary outcome is 28-day mortality.
Ethics and dissemination: Ethical approval to conduct the research has been obtained from all participating centers. Additionally, the results will be published in peer-reviewed journal.
Trial registration: The study was registered at International Standard Registered Clinical/soCial sTudy Number (ISRCTN) registry (ISRCTN10583582).},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/11108}
}