@article{ATM11597,
author = {Jordi Rello and Hakan Erdem},
title = {Preface},
journal = {Annals of Translational Medicine},
volume = {4},
number = {17},
year = {2016},
keywords = {},
abstract = {Roger Bone reported, twenty-five years ago, a consensus paper which was determinant for a common framework of sepsis. Immunological response to bacterial infection was identified as crucial in the diagnosis of sepsis, and nowadays we know that it involves an imbalance in the Th17 response. An overlap between clinical manifestations after bacterial injury and non-infectious injury, as burns, trauma or pancreatitis was acknowledged. In 2016, definitions have been revisited and the concept of severe sepsis has been erased, splitting infection in two categories, i.e., sepsis and septic shock (when lactate is increased and mean arterial pressure is low). However, the challenge of improving outcomes remains.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/11597}
}