@article{ATM13073,
author = {Karen K. Sayal and Geoffrey S. Higgins and Ester M. Hammond},
title = {Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity},
journal = {Annals of Translational Medicine},
volume = {4},
number = {24},
year = {2016},
keywords = {},
abstract = {Gliomas are the most frequently occurring brain tumour, of which glioblastomas (WHO grade IV gliomas) are the most common subtype and carry a particularly poor prognosis, leading to 5-year survival rates of just 9.8% (1,2). Radiation is an effective treatment modality although dose escalation is limited by the narrow therapeutic index. Consequently, there is a clear and unmet clinical need for effective radiosensitisation strategies for glioblastoma which enhance anti-tumour efficacy without increasing dose-limiting normal tissue toxicity. The paucity of effective clinically validated radiosensitisers further highlights the need for novel therapeutic targets for radiosensitisation of glioblastoma.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/13073}
}