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Dopamine in the ventral tegmental area facilitates emergence from general anesthesia

   
@article{ATM13492,
	author = {L. Stan Leung},
	title = {Dopamine in the ventral tegmental area facilitates emergence from general anesthesia},
	journal = {Annals of Translational Medicine},
	volume = {5},
	number = {4},
	year = {2017},
	keywords = {},
	abstract = {Taylor et al. (1) showed that optogenetic activation of dopaminergic neurons in the ventral tegmental area (VTA) during continuous, steady-state isoflurane-induced general anesthesia produced electrographic arousal, and restored the righting reflex in mice. Systemic administration of the D1 receptor antagonist SCH-23390 before optical stimulation greatly attenuated electrographic and behavioral arousal. Transfection of VTA neurons with a vector carrying channelrhodopsin 2 (ChR2) allowed optical activation, and optical stimulation in control mice transfected with a vector lacking ChR2 did not induce arousal.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/13492}
}