@article{ATM13667,
author = {Jan Gunst and Greet Van den Berghe},
title = {Blood glucose control in the ICU: how tight?},
journal = {Annals of Translational Medicine},
volume = {5},
number = {4},
year = {2017},
keywords = {},
abstract = {Fifteen years after the first randomized controlled trial (RCT) on tight blood glucose control (TGC) in the intensive care unit (ICU), the exact target of blood glucose control remains a matter of debate, especially since subsequent RCTs have found divergent results (1-4). Indeed, whereas the Leuven RCTs found that targeting normal for age fasting blood glucose levels with insulin clearly reduced short-term morbidity and mortality in critically ill adults and children (1-3), with the benefit maintained on the long term (5,6), the largest multicenter RCT (NICE-SUGAR) found excess mortality (4), which was attributed to an increased risk of severe hypoglycemia (7).},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/13667}
}