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The discovery of HLA-G-bearing extracellular vesicles: new perspectives in HLA-G biology

   
@article{ATM13722,
	author = {Giada Amodio and Silvia Gregori},
	title = {The discovery of HLA-G-bearing extracellular vesicles: new perspectives in HLA-G biology},
	journal = {Annals of Translational Medicine},
	volume = {5},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {In contrast to classical human histocompatibility antigen (HLA) class I molecules, HLA-G has been discovered quite recently, in 1990. Since its discovery several efforts have been made to define HLA-G biology and its role in regulating immune responses. The main distinctive characteristics of HLA-G are the limited protein variability, alternative mRNA splicing that generates seven different isoforms(both soluble and membrane-bound) with the ability to form multiple structures via disulfide bounds, and restricted expression to certain tissues (1). Moreover, the discovery that HLA-G binds different inhibitory receptors (i.e., ILT2 and ILT4, and KIR2DL4) led to the classification of HLA-G as a tolerogenic molecule (2).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/13722}
}