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Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network

   
@article{ATM156066,
	author = {Omar Abdelhalim and Mohammed Y. Youssef and Sawsan Al-Lababidi and Mohamed H. Eldesouki and Ahmed Mohamed and Mohammed Abusuliman and Mahmoud Nassar and Mohammad Abushanab and Ahmed Salem and Hassan Shaheen and Ahmed Aref and Khaled M. Elhusseiny and Chloe Lahoud and Zara Bhutta and Hazem Abosheaishaa},
	title = {Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network},
	journal = {Annals of Translational Medicine},
	volume = {14},
	number = {3},
	year = {2026},
	keywords = {},
	abstract = {Background: Patients with coexisting type 2 diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) represent a high-risk population with competing comorbidities, complex medication regimens, and overlapping inflammatory pathways. Although the role of sodium-glucose co-transporter-2 (SGLT2) inhibitors in managing type 2 diabetes is well-established, their impact on outcomes in diabetic patients with coexisting IBD remains unclear. This study aimed to investigate the association between SGLT2i use and hospitalization, intensive care unit (ICU) admission, mortality, IBD-related complications, and surgical procedures in diabetic patients with IBD.Methods: We conducted a retrospective cohort study using the TriNetX Global Collaborative Network. Cohort 1 comprised diabetic patients with IBD who received SGLT2 inhibitors with at least three dispensations within one year of IBD diagnosis, and Cohort 2 comprised diabetic patients with IBD never prescribed SGLT2i, matched on baseline characteristics, comorbidities, IBD-specific medications, and laboratory values, yielding 3,950 patients per cohort. Clinical outcomes were evaluated at 1 and 5 years following the index event.Results: At 1 year, hospitalization, ICU admission, and mortality were significantly lower in Cohort 1 [risk ratio (RR): 0.886, P},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/156066}
}