@article{ATM15685,
author = {Giuseppe Lippi and Camilla Mattiuzzi and Gianfranco Cervellin and Emmanuel J. Favaloro},
title = {Direct oral anticoagulants: analysis of worldwide use and popularity using Google Trends},
journal = {Annals of Translational Medicine},
volume = {5},
number = {16},
year = {2017},
keywords = {},
abstract = {Abstract: Background: Four direct oral anticoagulants (DOACs) have been approved for clinical use by many medicines regulatory agencies around the world. Due to increasing use of these drugs in routine practice, we planned an original study to investigate their worldwide diffusion using a popular Web-search engine.
Methods: Two electronic searches were performed using Google Trends, the former using the keywords “warfarin” AND “heparin” AND “fondaparinux”, and the latter using the keywords “warfarin” AND “dabigatran” AND “rivaroxaban” AND “apixaban” AND “edoxaban”, both using the search criterion “prescription drug”. No language restriction was applied, and the searches were carried out from the first date available in Google Trends (January 1st, 2004) to present time (June 1st, 2017).
Results: The median Google Trends score of warfarin (i.e., 86) was consistently higher than that of heparin (54; P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/15685}
}