@article{ATM17013,
author = {Xuqin Jiang and Xiaodong Mei and Huimei Wu and Xiaojuan Chen},
title = {D-dimer level is related to the prognosis of patients with small cell lung cancer},
journal = {Annals of Translational Medicine},
volume = {5},
number = {20},
year = {2017},
keywords = {},
abstract = {Background: Although the significance of D-dimer in cancer patients has been extensively studied and plasma D-dimer levels have been reported to be abnormally high in certain types of lung cancer patients, its prognostic value for small cell lung cancer (SCLC) remains largely unknown.
Methods: One hundred and seven newly diagnosed SCLC patients were enrolled in this study. Variables including the clinical features, pre-treatment levels of D-dimer, serum neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) were extracted. The correlations between D-dimer levels and prognosis of the patient were analysed with Kaplan-Meier survival analysis.
Results: Plasma D-dimer levels were elevated in 57.01% of patients. Patients with extensive stage disease had higher D-dimer levels compared with those at limited stage. D-dimer levels were positively correlated with NSE and CEA levels. The elevated D-dimer levels were significantly associated with the SCLC-related mortality. Patients with elevated D-dimer levels had a shorter median survival time than those with normal levels, and a significant difference existed between the two groups.
Conclusions: Increased D-dimer levels suggested a shorter survival time in SCLC patients. Pre-treatment D-dimer level is useful in estimating the prognosis of patients with SCLC.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/17013}
}