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Osimertinib in first-line treatment—is a comparison not proof?

   
@article{ATM18087,
	author = {Jacques Cadranel},
	title = {Osimertinib in first-line treatment—is a comparison not proof?},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {3},
	year = {2018},
	keywords = {},
	abstract = {Considerable progress has been made in the treatment of advanced non-small-cell lung carcinoma (NSCLC) harboring an epidermal growth factor receptor (EGFR) gene mutation (EGFR-NSCLC) since the publication of the BR21 trial (1). That trial showed erlotinib to have a modest effect compared with placebo in the second and subsequent lines of treatment in the all-comers NSCLC population.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/18087}
}