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No association between systemic complement activation and intensive care unit-acquired weakness

   
@article{ATM18846,
	author = {Esther Witteveen and Luuk Wieske and Friso M. de Beer and Nicole P. Juffermans and Camiel Verhamme and Marcus J. Schultz and Ivo N. van Schaik and Janneke Horn and on behalf of the BASIC study group},
	title = {No association between systemic complement activation and intensive care unit-acquired weakness},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {7},
	year = {2018},
	keywords = {},
	abstract = {Background: The main risk factors for intensive care unit-acquired weakness (ICU-AW) are sepsis, the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction. These risk factors are associated with systemic complement activation. We hypothesized that critically ill patients who develop ICU-AW have increased systemic complement activation compared to critically ill patients who do not develop ICU-AW. 
Methods: Complement activation products C3b/c, C4b/c and C5a were measured in plasma of ICU patients with mechanical ventilation for ≥48 hours. Samples were collected at admission to the ICU and for 6 consecutive days. ICU-AW was defined by a mean Medical Research Council (MRC) score },
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/18846}
}