%0 Journal Article
%T No association between systemic complement activation and intensive care unit-acquired weakness
%A Witteveen, Esther
%A Wieske, Luuk
%A Beer, Friso M. de
%A Juffermans, Nicole P.
%A Verhamme, Camiel
%A Schultz, Marcus J.
%A van Schaik, Ivo N.
%A Horn, Janneke
%A BASIC study group, on behalf of the
%J Annals of Translational Medicine
%D 2018
%B 2018
%9 
%! No association between systemic complement activation and intensive care unit-acquired weakness
%K 
%X Background: The main risk factors for intensive care unit-acquired weakness (ICU-AW) are sepsis, the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction. These risk factors are associated with systemic complement activation. We hypothesized that critically ill patients who develop ICU-AW have increased systemic complement activation compared to critically ill patients who do not develop ICU-AW.   Methods: Complement activation products C3b/c, C4b/c and C5a were measured in plasma of ICU patients with mechanical ventilation for ≥48 hours. Samples were collected at admission to the ICU and for 6 consecutive days. ICU-AW was defined by a mean Medical Research Council (MRC) score 
%U https://atm.amegroups.org/article/view/18846
%V 6
%N 7
%P 115
%@ 2305-5847