@article{ATM19375,
author = {Arpit Rao and Charles Wiggins and Richard C. Lauer},
title = {Survival outcomes for advanced kidney cancer patients in the era of targeted therapies},
journal = {Annals of Translational Medicine},
volume = {6},
number = {9},
year = {2018},
keywords = {},
abstract = {Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients.
Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013. Patients were divided into two cohorts based on the year of diagnosis—pre-TKI cohort [2000–2006] and TKI cohort [2007–2013]. Kaplan-Meier survival and multivariate Cox proportional hazards analyses were performed.
Results: A total of 14,976 patients were included in our study. Median age at diagnosis was 64 years (range, 18–89 years). Median (cancer-specific) overall survival was 10.0 months in the TKI cohort compared with 8.0 months in the pre-TKI cohort, corresponding to a 13% improvement in survival in the TKI area [hazard ratio (HR) for death 0.87; 95% confidence interval (CI), 0.84–0.91, P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/19375}
}