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Unmask the genetic backbone of ibrutinib-relapsed chronic lymphocytic leukemia progression and Richter transformation

   
@article{ATM19732,
	author = {Wei-Ge Wang and Xiao-Yan Zhou and Xiao-Qiu Li},
	title = {Unmask the genetic backbone of ibrutinib-relapsed chronic lymphocytic leukemia progression and Richter transformation},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {11},
	year = {2018},
	keywords = {},
	abstract = {In the issue of Blood Adv, Kadri et al. (1) reported a cohort of nine chronic lymphocytic leukemia (CLL) ibrutinib-relapsed patients with leukemia progression and Richter transformation. With the next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array, 18p deletion [del(18p)], together with del(17p)/TP53 mutations was found in CLL tumor cells in five out of nine patients before ibrutinib administration.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/19732}
}