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Genetic mitochondrial glycine amidinotransferase protein aggregate formation triggers microparticle sensing and kidney failure

   
@article{ATM20439,
	author = {Shrikant R. Mulay and Hans-Joachim Anders},
	title = {Genetic mitochondrial glycine amidinotransferase protein aggregate formation triggers microparticle sensing and kidney failure},
	journal = {Annals of Translational Medicine},
	volume = {6},
	number = {16},
	year = {2018},
	keywords = {},
	abstract = {Deposition of crystals or crystalline particles in various organs leads to diverse medical disorders (1). Misfolded or aggregated proteins can form crystalline or non-crystalline microparticles that activate similar molecular pathways of inflammation and cell death, for example—Alzheimer’s disease (amyloid-β aggregates) (2), Parkinson’s disease (α-synuclein misfolding) (3), or in monoclonal immunoglobulin-associated renal diseases (4,5).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/20439}
}