@article{ATM20921,
author = {Meng Liu and Fuxian Zhang},
title = {Administration routes affect thrombolytic effect of catheter-directed thrombolysis with pro-urokinase in treating deep vein thrombosis},
journal = {Annals of Translational Medicine},
volume = {6},
number = {16},
year = {2018},
keywords = {},
abstract = {Background: Deep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Catheter-directed thrombolysis (CDT) is a preferred treatment for DVT patients. The aim of this study is to evaluate the thrombolytic effect of CDT with pro-urokinase (pro-UK) in different administration routes.
Methods: An inferior vena cava (IVC) model was induced in 36 New Zealand white rabbits by catheter injury and placement of IVC filter. The animals were divided into 6 groups with 6 rabbits in each group: group A: systemic thrombolysis with intravenous injection; group B: CDT with pump infusion; group C: CDT with pulse injection; group D: CDT with combination of pump infusion and pulse injection; group E: catheter-directed aspiration thrombectomy; group F: mechanical thrombectomy. The thrombolytic effects were evaluated by color Doppler ultrasound and blood measurement of D-dimer and fibrinogen.
Results: The minimum effective concentration of pro-UK solution was identified. Two groups (group A and B) did not achieve successful thrombolysis. Among all catheter-directed administration groups, the rabbit groups that received pro-UK therapy through catheter-directed thrombolytic pump infusion combined with pulse injection (group D) showed the best thrombolysis effect. In contrast, catheter-directed aspiration thrombectomy (group E) is effective but not safe.
Conclusions: CDT with combination of pump infusion and pulse injection of pro-UK safely and significantly improves thrombolysis procedure in rabbits, suggesting potential benefits from the use of CDT in proximal DVT.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/20921}
}