@article{ATM22390,
author = {Chuanfei Zhan and Xinzheng Dai and Gefengqiang Shen and Xu Lu and Xuehao Wang and Ling Lu and Xiaofeng Qian and Jianhua Rao},
title = {Preoperative short-term fasting protects liver injury in patients undergoing hepatectomy},
journal = {Annals of Translational Medicine},
volume = {6},
number = {23},
year = {2018},
keywords = {},
abstract = {Background: Our previous study demonstrated that preoperative short-term fasting attenuates mice hepatic ischemia/reperfusion injury (IRI), which greatly piqued our interest in verifying if fasting produces similar protective effects in patients undergoing hepatectomy.
Methods: Eighty patients with liver tumors were randomized into control (Ctrl, n=40, preoperative fasting for 6 h) or fasting group (Fasting, n=40, preoperative fasting for 24 h). Serum was collected at pre-operation (Pre-Op), post-operation 1 day (POD-1), post-operation 3 days (POD-3), and post-operation 7 days (POD-7). Liver tissue was removed from the resected specimen.
Results: Sixty-three patients were eventually enrolled, with 33 in Ctrl and 30 in Fasting group. Our data showed that 24 h fasting effectively attenuated elevated sALT and sAST levels after operation (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/22390}
}