@article{ATM24583,
author = {Yueyao Du and Liheng Zhou and Yanping Lin and Kai Yin and Wenjin Yin and Jinsong Lu},
title = {Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer},
journal = {Annals of Translational Medicine},
volume = {7},
number = {7},
year = {2019},
keywords = {},
abstract = {Background: Germline genetic polymorphisms in certain genes are associated with response to anthracycline- and taxane-based neoadjuvant chemotherapy in breast cancer (BC). Recent evidence has indicated that microRNA (miRNA) let-7 expression is associated with response to chemotherapeutics. This study aims to evaluate the potential role of let-7 miRNA-related single nucleotide polymorphisms (mirSNPs) in the prediction of pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in locally advanced breast cancer (LABC).
Methods: We genotyped the SNPs that reside in and around miRNA let-7 binding sites of two target genes: hypoxia-inducible factor 1 subunit alpha inhibitor (HIF1AN) and claudin 12 (CLDN12). The distribution frequencies of the SNPs were genotyped in LABC patients who received taxane- and platinum-based neoadjuvant chemotherapy. Associations among tumour-relevant biomarkers, genotype and pathological complete response (pCR) were evaluated using Student’s t-test for continuous variables and the chi-square or Fisher’s exact tests for non-categorical variables. The modified odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated by a multivariate logistic regression analysis to explore the association of genotype with pCR.
Results: For rs11292, which is located in the 3’-untranslated region (UTR) of HIF1AN, significant differences were detected in codominant, dominant and overdominant models between the patients who achieved pCR and those who did not (non-pCR) (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/24583}
}