TY  - JOUR
AU  - Li, De-Qiang
AU  - Lv, Fei-Fei
AU  - Li, Zhong-Chun
AU  - Dai, Zhi-Yuan
AU  - Wang, Hong-Xia
AU  - Han, Yang
PY  - 2019
TI  - Anti-atherosclerotic effects between a combined treatment with simvastatin plus hirudin and single simvastatin therapy in patients with early type 2 diabetes mellitus
JF  - Annals of Translational Medicine; Vol 7, No 14 (July 31, 2019): Annals of Translational Medicine
Y2  - 2019
KW  - 
N2  - Background: This study aimed to investigate the efficacy and safety of simvastatin plus hirudin in preventing atherosclerosis in the patients with early type 2 diabetes mellitus (T2DM).   Methods: This was a 24-week, randomized, open-label and controlled study in which 150 outpatients initially diagnosed with T2DM were randomly assigned into either simvastatin (40 mg daily at night) plus hirudin (3 g thrice daily) group [combined group (CG) n=75] or simvastatin (40 mg once daily) group [monotherapy group (MG) n=75]. The therapeutic efficacy was evaluated by the score of carotid artery atherosclerosis, plaque size, peak systolic velocity (PSV) and end-diastolic velocity (EDV) on carotid ultrasonography at three and six months after treatment. Logistic regression analysis was used to investigate the correlation between treatment and carotid atherosclerosis.  Results: One hundred and thirty-one patients completed this study, and there were no significant differences in the dropout rate in the CG (14.67%) and the MG (10.67%). Significant difference was found in the incidence of adverse events in the CG compared with the MG (37.50% vs. 17.91%, P
UR  - https://atm.amegroups.org/article/view/26459