@article{ATM27414,
author = {Ye Shi and Jun Ma and Ying Xue and Jing Wang and Bin Yu and Ting Wang},
title = {The assessment of combined karyotype analysis and chromosomal microarray in pregnant women of advanced maternal age: a multicenter study},
journal = {Annals of Translational Medicine},
volume = {7},
number = {14},
year = {2019},
keywords = {},
abstract = {Background: Retrospectively analyzed the results of prenatal diagnosis and hoped to provide scientific clinical guidance of prenatal screening and diagnosis for the women in advanced maternal age (AMA).
Methods: In total, 4,224 women of AMA who accepted prenatal diagnosis by amniocentesis (AC) from two prenatal diagnosis centers were recruited for this study. After genetic counseling and informed consent, 3,475 women received karyotype analysis only, 703 were examined by both karyotype analysis and chromosomal microarray (CMA), while 46 cases selected CMA only. Both centers used the same detection platform, experimental scheme, and quality control standards.
Results: A total of 164 women with chromosomal abnormal results were found, the abnormality rate was 3.88% (164/4,224). Among them, 145 (3.4%, 145/4,224) cases were detected as abnormal chromosome number, 19 cases (0.4%, 19/4,224) as abnormal chromosome structure. Compared with simple AMA women, the abnormality rate was significantly increased in the AMA women who combined with other indications, particularly in number abnormalities (22.5% vs. 1.0%, P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/27414}
}