TY  - JOUR
AU  - Liu, Jiabin
AU  - Hua, Rui-Xi
AU  - Fu, Wen
AU  - Zhu, Jinhong
AU  - Jia, Wei
AU  - Zhang, Jiao
AU  - Zhou, Haixia
AU  - Cheng, Jiwen
AU  - Xia, Huimin
AU  - Liu, Guochang
AU  - He, Jing
PY  - 2019
TI  - MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study
JF  - Annals of Translational Medicine; Vol 7, No 18 (September 30, 2019): Annals of Translational Medicine
Y2  - 2019
KW  - 
N2  - Background: Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. MYC, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the MYC gene may lead to the deregulation of MYC proto-oncogene protein and thereby promote the initiation and development of tumors.  Methods: Here, we assessed the association between MYC gene associated polymorphisms and WT susceptibility by performing a case-control study with 355 cases and 1070 controls. Two MYC gene associated polymorphisms (rs4645943 C > T, rs2070583 A > G) were genotyped by TaqMan technique. Odds ratios (ORs) and 95% confidence intervals (CIs) were used for evaluating the association between these two polymorphisms and WT susceptibility.  Results: No significant association was detected between the selected polymorphisms and WT risk in the overall analysis as well as stratification analysis.  Conclusions: These results indicate that neither of two selected MYC gene associated polymorphisms might affect WT susceptibility in the Chinese population. Large well-designed studies with diverse ethnicities are warranted to verify these results.
UR  - https://atm.amegroups.org/article/view/28745