@article{ATM28815,
author = {Aharon Y. Cohen and Waleed Kian and Laila C. Roisman and Dina Levitas and Nir Peled and Yulia Dudnik},
title = {Are we facing a cure in lung cancer?—KEYNOTE-001 insights},
journal = {Annals of Translational Medicine},
volume = {7},
number = {Suppl 6},
year = {2019},
keywords = {},
abstract = {Pembrolizumab is a humanized monoclonal antibody that blocks the programmed death 1 receptor (PD-1) and has antitumor activity in advanced non-small-cell lung cancer (NSCLC). The phase 1 trial first published in 2015, included a total of 495 advanced NSCLC patients. The patients received pembrolizumab at a dose of either 2 or 10 mg per kilogram of body weight every 3 weeks or 10 mg per kilogram every 2 weeks with progression-free survival (PFS) of 3.7 months and median duration of response (DOR) of 12.5 months. Among all patients, the median overall survival (OS) was 12.0 months. In patients with a PD-L1 immunohistochemistry [tumor proportion score (TPS)] score of at least 50% the median PFS was 6.3 months and the response rate was 45.2%, thus, the median OS was not reached (1).},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/28815}
}