%0 Journal Article
%T BRAF mutant metastatic colorectal cancers: new arrows in our quiver
%A Cremolini, Chiara
%A Moretto, Roberto
%A Zucchelli, Gemma
%A Falcone, Alfredo
%J Annals of Translational Medicine
%D 2019
%B 2019
%9 
%! BRAF mutant metastatic colorectal cancers: new arrows in our quiver
%K 
%X BRAF mutations occur in 8–12% of metastatic colorectal cancers (mCRC) and more than 95% of them consist in a T>A transversion in exon 15 resulting in an amino acid substitution from valine to glutamic acid (V600E) that is able to increase BRAF kinase activity by approximately  10-fold (1,2).
%U https://atm.amegroups.org/article/view/28956
%P S367
%@ 2305-5847