TY  - JOUR
AU  - Li, Cong
AU  - Su, Dongfang
AU  - Xie, Chuanbo
AU  - Chen, Qichen
AU  - Zhou, Jianguo
AU  - Wu, Xiaojun
PY  - 2019
TI  - Lymphadenectomy is associated with poor survival in patients with gastrointestinal stromal tumors
JF  - Annals of Translational Medicine; Vol 7, No 20 (October 31, 2019): Annals of Translational Medicine
Y2  - 2019
KW  - 
N2  - Background: Current clinical practice suggests lymphadenectomy for gastrointestinal stromal tumor (GIST) patients with enlarged lymph nodes, but little is known about the influence of lymphadenectomy on long-term survival.  Methods: This population-based study consisted of 3,819 non-metastatic GIST patients diagnosed between January 1st, 2001, to December 31st, 2015, from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier methods and Cox proportion regression models were used to compare differences in overall survival (OS) and cancer-specific survival (CSS) between the lymphadenectomy group and non-lymphadenectomy group.  Results: Among the 3,819 GIST patients, 1,202 received lymphadenectomy and 2,617 did not receive lymphadenectomy. Lymphadenectomy was associated with poor OS (adjusted HR =1.25, 95% CI: 1.06–1.47) and CSS (adjusted HR =1.32, 95% CI: 1.07–1.64) in GIST patients. This was especially evident in GIST patients with a tumor size less than 2 cm (OS, HR =1.91, 95% CI: 0.79–4.60 and CSS, HR =6.37, 95% CI: 1.85–21.90), who were more than 40 years old (OS, HR =1.28, 95% CI: 1.08–1.51 and CSS, HR =1.36, 95% CI: 1.09–1.70), and with a stomach tumor (OS, HR =1.39, 95% CI: 1.12–1.72 and CSS, HR =1.77, 95% CI: 1.33–2.35).  Conclusions: In conclusion, contrary to what was previously presumed, lymphadenectomy was associated with an increased and not a decreased risk of mortality in GIST patients.
UR  - https://atm.amegroups.org/article/view/30241