@article{ATM30610,
author = {Zeming Liu and Sichao Chen and Yihui Huang and Di Hu and Wen Zeng and Min Wang and Wei Zhou and Danyang Chen and Haifeng Feng and Wei Wei and Chao Zhang and Ling Zhou and Liang Guo},
title = {Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer},
journal = {Annals of Translational Medicine},
volume = {7},
number = {20},
year = {2019},
keywords = {},
abstract = {Background: Detection of distant metastasis (DM) is important in differentiated thyroid cancer (DTC). This study aimed to investigate the synergic effects of histology subtype, tumor size, and lymph node metastasis (LNM) status on the occurrence of DM in DTC.
Methods: We collected data of 96,788 patients with DTC. Univariate and multivariate analyses were conducted to identify the risk factors of DM. Relative excess risk of synergic effect, attributable proportion of synergic effect, and synergy index were then calculated to assess synergic effects. Further, Kaplan-Meier method using the log-rank test and receiver operating characteristic (ROC) curves were utilized.
Results: Age at diagnosis (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/30610}
}