%0 Journal Article
%T miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway
%A Yu, Shuang
%A Cao, Siting
%A Hong, Shubin
%A Lin, Xiaorong
%A Guan, Hongyu
%A Chen, Shuwei
%A Zhang, Quan
%A Lv, Weiming
%A Li, Yanbing
%A Xiao, Haipeng
%J Annals of Translational Medicine
%D 2019
%B 2019
%9 
%! miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway
%K 
%X Background: It is well known that the dysregulation of microRNAs (miRNAs) has been identified in papillary thyroid carcinoma (PTC), but their roles in the progression and metastasis of PTC remain unclear. MicroRNA-3619-3p (miR-3619-3p) is associated with cancer progression as an oncogene which is predicted to target at the Wnt/β-catenin signaling pathway. Our study aimed to investigate the role of miR-3619-3p on PTC cell migration and invasion, as well as the underlying mechanisms.  Methods: The expression of miR-3619-3p in 36 PTC tissues and corresponding tumor-adjacent tissues, as well as 3 PTC cell lines (BCPAP, K1, TPC-1) and the normal thyroid epithelial cell line (N-thy-ori 3-1) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between miR-3619-3p expression and clinicopathologic status of PTC patients was analyzed. Migration, invasion, and wound healing, were used to evaluate the role of miR-3619-3p in PTC. The activation of β-catenin and the possible molecular pathway were detected by western blotting.   Results: The expression of miR-3619-3p in PTC tissues was significantly higher than the corresponding tumor-adjacent tissues (P
%U https://atm.amegroups.org/article/view/31044
%V 7
%N 22
%P 643
%@ 2305-5847