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Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3+ T cells

   
@article{ATM33007,
	author = {Chuangye Ni and Xiaojie Gan and Xu Li and Han Sun and Zhen Chen and Hao Lu},
	title = {Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3+ T cells},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {23},
	year = {2019},
	keywords = {},
	abstract = {Background: Acute graft-versus-host disease (aGVHD) is a medical complication which may result in significant morbidity and mortality after transplantation. The aim of this study investigated the therapeutic effect and underlying mechanism of 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in the treatment of aGVHD. 
Method: An aGVHD model was built by transferring splenocytes of B6 mice into B6D2F1 mice. 1α,25(OH)2D3 was added to evaluate the protective function to aGVHD; the phenotype and cytokine expression profile of spleen cells from the aGVHD model were determined using flow cytometry 2 weeks after the model is established.
Result: Administration of 1α,25(OH)2D3 significantly slowed aGVHD progression and improved survival of B6D2F1 recipients of grafted B6 splenocytes. 1α,25(OH)2D3 treatment also resulted in an increased number of CD4+Foxp3+ regulatory T cells (Tregs) but decreased the number of CD4+IL-4+ cells. In vitro analysis demonstrated that 1α,25(OH)2D3 directly increased forkhead box P3 (Foxp3) and IL-10 expression and enhanced the function of induced Tregs (iTregs).
Conclusions: This analysis indicated that the effect of 1α,25(OH)2D3 is mediated in part by improving the number of Tregs. 1α,25(OH)2D3 administration thus represents a viable approach for treating aGVHD.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/33007}
}