@article{ATM33197,
author = {Kun Liu and Chengya Huang and Meiying Xu and Jingxiang Wu and Inez Frerichs and Knut Moeller and Zhanqi Zhao},
title = {PEEP guided by electrical impedance tomography during one-lung ventilation in elderly patients undergoing thoracoscopic surgery},
journal = {Annals of Translational Medicine},
volume = {7},
number = {23},
year = {2019},
keywords = {},
abstract = {Background: To examine the influence of positive end-expiratory pressure (PEEP) settings on lung mechanics and oxygenation in elderly patients undergoing thoracoscopic surgery.
Methods: One hundred patients aged >65 years were randomly allocated into either the PEEP5 or the electrical impedance tomography (EIT) group (PEEPEIT). Each group underwent volume-controlled ventilation (tidal volume 6 mL/kg predicted body weight) with the PEEP either fixed at 5 cmH2O or set at an individualized EIT setting. The primary endpoint was the ratio of the arterial oxygen partial pressure to the fractional inspired oxygen (PaO2/FiO2). The secondary endpoints included the driving pressure, and dynamic respiratory system compliance (Cdyn). Other outcomes, such as the mean airway pressure (Pmean), mean arterial pressure (MAP), lung complications and the length of hospital stay were explored.
Results: The optimal PEEP set by EIT was significantly higher (range from 9–13 cmH2O) than the fixed PEEP. PaO2/FiO2 was 47 mmHg higher (95% CI: 7–86 mmHg; P=0.021), Cdyn was 4.3 mL/cmH2O higher (95% CI: 2.1–6.7 cmH2O; P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/33197}
}