@article{ATM3396,
author = {Vaclav Vetvicka and Carlos Oliveira},
title = {β(1-3)(1-6)-D-glucans modulate immune status in pigs: potential importance for efficiency of commercial farming},
journal = {Annals of Translational Medicine},
volume = {2},
number = {2},
year = {2014},
keywords = {},
abstract = {Background: In face of the challenge of the emergent diseases and the current efforts of the governments to create conditions to ban growth-promoting antibiotics and to improve efficiency of the commercial farming, new opportunities are created for natural, highly effective and cost affordable immunomodulators; able to induce and enhance resistance against diseases and to reduce farming-related stress. Supplementation of animal feed with β(1-3) (1-6)-D-glucans has been repeatedly shown to modulate the immune system ant to influence growth characteristics of farmed animals.
Materials and methods: In our study we focused on evaluation of effects of an insoluble, fungi-derived β(1-3) (1-6)-D-glucan as dietary supplement in piglets. We measured the growth, phagocytosis of peripheral blood cells and interleukin 2 (IL-2) and tumor necrosis factor alpha (TNF-α) production after feeding with 15 mg of glucan/kg/day.
Conclusions: Following supplementation, β(1-3)(1-6)-D-glucan has been shown to stimulate growth, phagocytic activity, and IL-2 production. In addition, it significantly lowered the cortisol and TNF-α levels after lipopolysaccharide (LPS) challenge.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/3396}
}