@article{ATM34953,
author = {Wei-Hong Zheng and Xiao-Jun He and Fo-Ping Chen and Li Lin and Xiao-Dan Huang and Hua-Qiang Zhou and Jia Kou and Jia-Wei Lv and Jun Ma and Guan-Qun Zhou and Ying Sun},
title = {Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma},
journal = {Annals of Translational Medicine},
volume = {8},
number = {4},
year = {2020},
keywords = {},
abstract = {Background: Significance of plasma Epstein-Barr virus deoxyribonucleic acid (EBV DNA)— a proven robust indicator for nasopharyngeal carcinoma (NPC)—is not yet clarified in risk stratification of metastatic NPC (mNPC). We aim to establish effective M1 stage subdivisions in mNPC by integrating radiological features and EBV DNA at diagnosis of metastasis (mEBV DNA).
Methods: The study comprised 1,007 mNPC patients, including 817 metachronous mNPC (mmNPC) patients randomized into training (n=613) and internal validation (n=204) cohorts, and 190 synchronous mNPC (smNPC) patients defined as smNPC validation cohort. Primary clinical end-point was overall survival (OS). Covariate inclusion to recursive partitioning analysis (RPA)-generated risk stratification was qualified by a multivariable two-sided P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/34953}
}