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HIF-1α regulated tongue squamous cell carcinoma cell growth via regulating VEGF expression in a xenograft model

   
@article{ATM4297,
	author = {Jun Liang and Zhaoqiang Zhang and Lizhong Liang and Yun Shen and Kexiong Ouyang},
	title = {HIF-1α regulated tongue squamous cell carcinoma cell growth via regulating VEGF expression in a xenograft model},
	journal = {Annals of Translational Medicine},
	volume = {2},
	number = {9},
	year = {2014},
	keywords = {},
	abstract = {Objective: We aimed to study the mechanism of hypoxia-inducible factor 1 alpha (HIF-1α) regulating the cell proliferation of tongue squamous cell carcinoma (TSCC) via vascular endothelial growth factor (VEGF). 
Methods: We used RNA interference (RNAi) technique, transfected chemically synthesized siRNA against HIF-1α into CAL-27 cells, and detected the expression of HIF-1α and VEGF by real time-PCR and Western blotting in order to find out if HIF-1α regulated the expression of VEGF. A xenograft experiment was carried out to observe the role of HIF-1α on the tumor growth of tongue squamous cell carcinoma. 
Results: HIF-1α and VEGF mRNA expression was significantly downregulated 36 and 48 h after transfection (P},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/4297}
}