@article{ATM6030,
author = {Luca Bertolaccini and Andrea Viti and Chiara Tavella and Roberto Priotto and Donatella Ghirardo and Maurizio Grosso and Alberto Terzi and on the behalf of the SOS Study Group},
title = {Lung cancer detection with digital chest tomosynthesis: first round results from the SOS observational study},
journal = {Annals of Translational Medicine},
volume = {3},
number = {5},
year = {2015},
keywords = {},
abstract = {Objective: Baseline results of the Studio OSservazionale (SOS), observational study, a single-arm observational study of digital chest tomosynthesis for lung cancer detection in an at-risk population demonstrated a detection rate of lung cancer comparable to that of studies that used low dose CT scan (LDCT). We present the results of the first round
Methods: Totally 1,703 out of 1,843 (92%) subjects who had a baseline digital chest tomosynthesis underwent a first round reevaluation after 1 year.
Results: At first round chest digital tomosynthesis, 13 (0.7%) subjects had an indeterminate nodule larger than 5 mm and underwent low-dose CT scan for nodule confirmation. PET/CT study was obtained in 10 (0.5%) subjects and 2 subjects had a low-dose CT follow up. Surgery, either video-assisted thoracoscopic or open surgery for indeterminate pulmonary nodules was performed in 10 (0.2%) subjects. A lung cancer was diagnosed and resected in five patients. The lung cancer detection rate at first round was 0.3% (5/1,703).
Conclusions: The detection rate of lung cancer at first round for tomosynthesis is comparable to rates reported for CT. In addition, results of first round digital chest tomosynthesis confirm chest tomosynthesis as a possible firstline lung cancer-screening tool.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/6030}
}