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High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice

   
@article{ATM6187,
	author = {Jiezhong Chen and Xu-Feng Huang},
	title = {High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice},
	journal = {Annals of Translational Medicine},
	volume = {3},
	number = {6},
	year = {2015},
	keywords = {},
	abstract = {Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet.
Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice.
Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/6187}
}