@article{ATM6187,
author = {Jiezhong Chen and Xu-Feng Huang},
title = {High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice},
journal = {Annals of Translational Medicine},
volume = {3},
number = {6},
year = {2015},
keywords = {},
abstract = {Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet.
Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice.
Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 times of polyps compared to the low fat fed mice (P<0.05). Although the DR mice tended to have more polyps than the low-fat diet fed mice, this was not statistically significant. The DIO mice could have an increased polyp formation due to obesity-related cancer risk factors and different gene expression from DR mice.
Conclusions: DIO mice could be used as an appropriate model for studying obesity-associated colon cancer; however DR mice are not suitable because they don’t show any significant weight gains to indicate obesity.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/6187}
}