@article{ATM6188,
author = {Raffaele Califano and Floriana Morgillo and Ramon Andrade De Mello and Giannis Mountzios},
title = {Role of mesenchymal-epithelial transition amplification in resistance to anti-epidermal growth factor receptor agents},
journal = {Annals of Translational Medicine},
volume = {3},
number = {6},
year = {2015},
keywords = {},
abstract = {All patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with an EGFR-tyrosine kinase inhibitor (EGFR-TKI) such as gefitinib, erlotinib or afatinib will progress after a median of 9-12 months. So far, development of a secondary T790M mutation represents the most common (approximately 60%) mechanism of resistance to these drugs. The relative rarity of mesenchymal-epithelial transition (MET) amplification in NSCLC suggests that this event plays a limited role in primary resistance to EGFR-TKI. In contrast, MET gene amplification has been detected as a secondary event representing one of the most relevant mechanisms involved in the acquired resistance to EGFR-TKIs both in preclinical and clinical studies. The aim of this review is to discuss the role of MET amplification as a mechanism of resistance to anti-EGFR therapies and to review strategies which aim at overcoming this mechanism of resistance, including studies assessing drug combinations targeting both EGFR and MET pathways.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/6188}
}