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A pooled analysis of stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small cell lung cancer: is failure to recruit patients into randomized trials also an answer to the research question?

   
@article{ATM6719,
	author = {Carsten Nieder and Nicolaus Andratschke and Matthias Guckenberger},
	title = {A pooled analysis of stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small cell lung cancer: is failure to recruit patients into randomized trials also an answer to the research question?},
	journal = {Annals of Translational Medicine},
	volume = {3},
	number = {11},
	year = {2015},
	keywords = {},
	abstract = {Non-small cell lung cancer (NSCLC) is among the most common cancers and biggest health care challenges in large parts of the world. Patients with locally advanced NSCLC comprise a heterogeneous group and many of them have unsatisfactory outcomes despite aggressive multimodal treatment approaches. Those with stage I disease (no distant or lymph node metastases; N0 M0) have the highest chance for cure. In the current classification system T-stage is based on primary tumor size (T1a max. 2.0 cm, T1b 2.1-3.0 cm, T2a 3.1-5.0 cm). Tumors larger than 5 cm are classified as stage II, even in the absence of lymph node metastases. In addition stage I requires that these tumors are surrounded by lung or visceral pleura and do not invade the main bronchus. Such tumors rarely cause any clinical symptoms, making early detection at this curable stage both challenging and crucial. Screening of high-risk patients using low-dose thoracic computed tomography (CT) imaging is therefore advocated.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/6719}
}