@article{ATM7081,
author = {Amr Hasan and Massimiliano Mazzone},
title = {Sixty shades of oxygen—an attractive opportunity for cancer immunotherapy},
journal = {Annals of Translational Medicine},
volume = {3},
number = {13},
year = {2015},
keywords = {},
abstract = {Tumors evade the cytotoxic activity of T lymphocytes by secreting adenosine in the extracellular matrix which limits the infiltration and activation of cytotoxic T lymphocytes (CTLs), and this process is strongly fostered by the hypoxic microenvironment that characterizes most of the cancer types. A paper recently published in Science Translational Medicine by Hatfield et al. found that respiratory hyperoxygenation can promote tumor regression in preclinical models of cancer by re-activating the antitumoral function of CTLs and natural killer (NK) cells.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/7081}
}