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Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma

   
@article{ATM8036,
	author = {Marco Ruella and Bruce Levine},
	title = {Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma},
	journal = {Annals of Translational Medicine},
	volume = {4},
	number = {1},
	year = {2015},
	keywords = {},
	abstract = {In a recent issue of the journal Science Translational Medicine, Dr. Johnson and our colleagues at the University of Pennsylvania reported on the rational development and characterization of humanized anti-epidermal growth factor receptor variant III (EGFRvIII) chimeric antigen receptor (CAR) T cells for glioblastoma (1). In this article, the authors describe the successful preclinical validation of a highly-selective humanized anti-EGFRvIII CAR T cell product that is currently employed in a phase I trial open at the University of Pennsylvania and the University of California San Francisco for patients with glioblastoma (NCT02209376).},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/8036}
}