@article{ATM8740,
author = {Mui Teng Chua and Win Sen Kuan},
title = {Venous-to-arterial carbon dioxide differences and the microcirculation in sepsis},
journal = {Annals of Translational Medicine},
volume = {4},
number = {3},
year = {2015},
keywords = {},
abstract = {Assessment of the microcirculation has been of particular interest in the management of septic shock for over a decade (1,2). It has garnered more attention in light of conflicting data recently on oxygen-derived parameters in patients with sepsis (3). Microcirculatory dysfunction has been linked to organ failure despite adequate macro-hemodynamic stability (4).The microcirculatory perfusion is regulated by the myogenic, metabolic and neurohumoral systems, which in turn affect the arteriolar tone, driving pressure, capillary patency and hemorheology (4). In septic states, perfusion pressure and deformability of cells are reduced, and arteriolar constriction ensues; the end-result is shunting of blood, bypassing essential areas of capillary exchange (5). These changes debilitate the microcirculation and impede tissue oxygenation, resulting in impaired organ functions. Moreover, with stasis in the capillary bed and inflammatory factors released from injured cells that cannot be cleared due to deficient flow, the microcirculation becomes a nidus for continued bacterial growth and persistent insult, sustaining the toxemia and acidemia.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/8740}
}