@article{ATM8950,
author = {Yong Liang and Hua Peng},
title = {STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy},
journal = {Annals of Translational Medicine},
volume = {4},
number = {3},
year = {2016},
keywords = {},
abstract = {Local irradiation has been broadly used in the treatment of primary and metastatic tumors. It is commonly believed that treatment effect of radiation is based on a direct killing of cancer cells. However, recent studies have gradually found that tumor regression following ablative irradiation mainly depends on type I interferon signaling and CD8+ T cell response. In this issue of Immunity, Deng and colleagues (1) found that anti-tumor effects of radiation are contributed by both innate and adaptive immune responses. They present compelling evidence that cytosolic DNA sensing pathways bridge the known irradiation-mediated DNA damage to anti-tumor immune response.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/8950}
}