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STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy

  
@article{ATM8950,
	author = {Yong Liang and Hua Peng},
	title = {STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy},
	journal = {Annals of Translational Medicine},
	volume = {4},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Local irradiation has been broadly used in the treatment of primary and metastatic tumors. It is commonly believed that treatment effect of radiation is based on a direct killing of cancer cells. However, recent studies have gradually found that tumor regression following ablative irradiation mainly depends on type I interferon signaling and CD8+ T cell response. In this issue of Immunity, Deng and colleagues (1) found that anti-tumor effects of radiation are contributed by both innate and adaptive immune responses. They present compelling evidence that cytosolic DNA sensing pathways bridge the known irradiation-mediated DNA damage to anti-tumor immune response.},
	issn = {2305-5847},	url = {https://atm.amegroups.org/article/view/8950}
}