@article{ATM9424,
author = {Giuseppe Lippi and Claudia Lo Cascio and Giorgio Brocco and Elisa Danese and Martina Montagnana and Antonella Bassi and Beatrice Caruso and Chiara Bovo and Gian Luca Salvagno},
title = {High-density lipoprotein cholesterol values independently and inversely predict cardiac troponin T and I concentration},
journal = {Annals of Translational Medicine},
volume = {4},
number = {10},
year = {2016},
keywords = {},
abstract = {Background: This retrospective study was planned to establish potential associations between circulating values of cardiac troponins and those of conventional blood lipids.
Methods: The study population consisted of patients attending an inpatient clinic of the University Hospital of Verona during the year 2015 as part of routine cardiovascular risk assessment. No exclusion criteria were applied. Serum lipids including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were measured using reference enzymatic techniques, whereas troponin T (TnT) was measured using a high-sensitivity (HS) immunoassay. A second analysis was also performed in the General Hospital of Verona, extracting data from the local laboratory database of all patients in whom troponin I (TnI) and blood lipids were simultaneously measured during the same year.
Results: In univariate analysis, HS-TnT was found to be associated with age, sex, TC, LDL-C, HDL-C, but not with TG. In multivariate linear regression analysis, age (positive correlation; P50 ng/L was higher in subjects with HDL-C 50 ng/L was also higher in elderly subjects than in younger ones (OR, 2.10; 95% CI, 1.15–3.84). The combination of age and HDL-C explained 35% of overall variability of TnT concentration. In the second analysis, HDL-C was also found to be an independent and negative predictor of TnI in multivariate linear regression analysis (P=0.010). The combination of age and HDL-C explained approximately 28% of the overall variability of TnI concentration.
Conclusions: Our study suggests that HDL-C values inversely predict cardiac troponins concentration irrespective of age, sex and other blood lipids.},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/9424}
}