Vps4A-mediated tumor suppression upon exosome modulation?

In cancer, communication between tumor cells and components of its surrounding microenvironment is critical for tumor growth, progression and metastatic potential (1). Components of the tumor microenvironment include extracellular matrix structures, fibroblasts (myofibroblasts), immune-reactive and inflammatory cells, and endothelial cells. Importantly, therapeutic opportunities may be opened up by combined targeting of tumor cells and their microenvironment (2). In this regard, better understanding of the cellular mechanisms mediating the communication between tumor cells and their microenvironment is urgently required.