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Challenges in Clinical Trials

This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

ATM Annual Report 2022

Greetings from the editorial office of ATM. We wish you a happy new year in 2023. In 2022, ATM has made great progress under the joint-efforts of experts worldwide.

The number of total citations of ATM has significantly increased to 53,650 in 2022.
The pageviews of ATM journal website is increasing significantly, with a total of 2,477,514 hits in 2022.

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

While China’s academic field is flourishing, ATM is blooming and become a choice of publication venue for more and more recognized affiliations. For ATM, it is precisely a type of recognition—by the country's top academic institutions and the most important think tanks in the country in the form of publication venue choice—that makes ATM stay in the scientific research fronts and able to further realize its mission of translating between bench and bedside. ATM's educational value is mostly based on the objective opinions of a group of field experts within the scientific community.

Reviewer of the Month (2023)

In 2023, ATM reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Outstanding Authors (2023)

In 2023, many ATM authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

The Modern Plastic and Reconstructive Surgeon – Collaborator, Innovator, Leader (Ongoing)

This special series on “The Modern Plastic and Reconstructive Surgeon – Collaborator, Innovator, Leader” is edited by Dr. Johnny Ionut Efanov, from the Division of Plastic and Reconstructive Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

Foot and Ankle Surgery (Ongoing)

This special series on “Foot and Ankle Surgery” is edited by Dr. Albert T. Anastasio from Department of Orthopaedic Surgery, Duke University Hospital, and aims to provide an updated overview of the most recent acquisitions and future perspectives.

Breast Reconstruction

This series of Annals of Translational Medicine presents a collection of reviews and surgical technique articles on the current state-of-the-art in breast reconstruction.

Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Endovascular Interventions in Trauma

Trauma is a leading cause of death and disability and predominately effects young patients. Trauma teams include many health care professionals from many subspecialties. Endovascular specialists such as interventional radiologists and vascular surgeons play an ever growing role in this team and in the care of these patients. In this focused series on endovascular interventions in trauma, articles will discuss the endovascular treatment of traumatic aortic injury, splenic, hepatic, renal pelvic and extremity trauma. Additionally, we include an article on the emerging technology of resuscitative endovascular balloon occlusion of the aorta (REBOA).

Highlights in Anesthesia and Critical Care Medicine (Ongoing)

Guest Editors: Tobias Eckle and Benjamin Scott (Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA)

Lung Cancer Management—The Next Decade (Ongoing)

This special series on “Lung Cancer Management—The Next Decade” is edited by Dr. Calvin S. H. Ng. Lung cancer remains a disease associated with high morbidity and mortality. It is only in the past decade or so that newer forms of therapies have gradually become available. Targeted and immunotherapies, specialized radiation ion therapies; and operative approaches that are more tailored to the individual with improved precision and lower surgical trauma have been in rapid development.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

Annals of Translational Medicine (ATM) is now a member of Committee on Publication Ethics (COPE)

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 11, No 11 (October, 2023)

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Endorsement

Annals of Translational Medicine is endorsed by the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, the Brazilian Society of Thoracic Surgery(SBCT) and the Hellenic Cooperative Oncology Group.

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Scope highlights of Annals of Translational Medicine based on a review of the history, definition, and scope of translational medicine

Kaiping Zhang, Yaling Cheng, Yan Peng, Fangyuan Jiang, Chundong Zhang, Calvin S. H. Ng, Rafael Rosell, Jimmy T. Efird, Amos Lal, Francesco Nappi, Ralf Weiskirchen, Shizuka Uchida, Mui Teng Chua, Riccardo D’Ambrosi

Annals of Translational Medicine

2023;

(11)

:381

| https://dx.doi.org/10.21037/atm-23-1798

(October 2023)

PDF Pages: 381 Full Text (933) Peer Review File COI Form Open Access

Original Article | Drug and Biomaterials Screening and Development

Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis

Jiawen Wu, Zhongmou Sun, Daowei Zhang, Hongli Liu, Jihong Wu, Shenghai Zhang

Annals of Translational Medicine

2023;

(11)

:382

| https://dx.doi.org/10.21037/atm-22-3557

(October 2023)

PDF Pages: 382 Full Text (487) Reporting Checklist Peer Review File COI Form Open Access

Surgical Technique | Data-Driven Clinical Practice and Policy Making

Practical oncoplastic surgery techniques needed for practice

Salvatore M. Nardello, Joshua A. Bloom, Kerry A. Gaffney, Meera Singhal, Sarah Persing, Abhishek Chatterjee

Annals of Translational Medicine

2023;

(11)

:383

| https://dx.doi.org/10.21037/atm-23-1536

(October 2023)

PDF Pages: 383 Full Text (376) Reporting Checklist Peer Review File COI Form Open Access

Review Article | Basic and Mechanism Sciences

Regulatory effects of nutritional and metabolic disorders on vascular calcification in chronic kidney disease: a narrative review

Yuqin Xiong, Yang Yu, Baihai Su

Annals of Translational Medicine

2023;

(11)

:384

| https://dx.doi.org/10.21037/atm-22-5358

(October 2023)

PDF Pages: 384 Full Text (386) Reporting Checklist Peer Review File COI Form Open Access

Implant-based breast surgery and capsular formation: when, how and why?—a narrative review

Andrew Gorgy, Natasha Barone, Hillary Nepon, Jacquie Dalfen, Johnny Ionut Efanov, Peter Davison, Joshua Vorstenbosch

Annals of Translational Medicine

2023;

(11)

:385

| https://dx.doi.org/10.21037/atm-23-131

(October 2023)

PDF Pages: 385 Full Text (706) Reporting Checklist COI Form Open Access

Review Article | Clinical Studies

Narrative review—diagnosing and managing malignant epidural spinal cord compression: an evidence-based approach

Zarique Z. Akanda, Michael J. McKay

Annals of Translational Medicine

2023;

(11)

:386

| https://dx.doi.org/10.21037/atm-22-3076

(October 2023)

PDF Pages: 386 Full Text (303) Reporting Checklist Peer Review File COI Form Open Access

Treatment strategies for complex ankle fractures—current developments summarized in a narrative review

Olivia Mair, Patrick Pflüger, Marc Hanschen, Peter Biberthaler, Moritz Crönlein

Annals of Translational Medicine

2023;

(11)

:387

| https://dx.doi.org/10.21037/atm-23-1173

(October 2023)

PDF Pages: 387 Full Text (361) Reporting Checklist Peer Review File COI Form Open Access

Review Article | Data-Driven Clinical Practice and Policy Making

New frontiers in intraoperative neurophysiologic monitoring: a narrative review

Anthony M. Oliva, Julio Montejano, Colby G. Simmons, Scott A. Vogel, Carlos F. Isaza, Claudia F. Clavijo

Annals of Translational Medicine

2023;

(11)

:388

| https://dx.doi.org/10.21037/atm-22-4586

(October 2023)

PDF Pages: 388 Full Text (434) Reporting Checklist Peer Review File COI Form Open Access

Update in lung transplantation: anesthetic considerations

Ashley V. Fritz, Miguel T. Teixeira, Saumil J. Patel, Melissa Burtoft, Archer Kilbourne Martin

Annals of Translational Medicine

2023;

(11)

:389

| https://dx.doi.org/10.21037/atm-22-4602

(October 2023)

PDF Pages: 389 Full Text (406) Peer Review File COI Form Open Access

Review Article | Emerging Therapeutics

A treatment algorithm for reconstruction of soft tissue defects in the hand: a narrative review

Panu H. Nordback, Matti Hakkarainen, Simo Mattila

Annals of Translational Medicine

2023;

(11)

:390

| https://dx.doi.org/10.21037/atm-23-201

(October 2023)

PDF Pages: 390 Full Text (317) Reporting Checklist COI Form Open Access

Updates in peripheral nerve surgery of the upper extremity: diagnosis and treatment options

Ruth En Si Tan, Shubashri Jeyaratnam, Aymeric Y. T. Lim

Annals of Translational Medicine

2023;

(11)

:391

| https://dx.doi.org/10.21037/atm-23-1500

(October 2023)

PDF Pages: 391 Full Text (362) Peer Review File COI Form Open Access

Case Report | Clinical Studies

Two-stage free latissimus dorsi flap for the management of a voluminous enterocutaneous fistula in a patient with Ehlers-Danlos syndrome: a case report

Alexandre G. Lellouch, Olivier Mathieu, Curtis L. Cetrulo Jr, Emilia Ragot, Mehdi Karoui

Annals of Translational Medicine

2023;

(11)

:392

| https://dx.doi.org/10.21037/atm-23-826

(October 2023)

PDF Pages: 392 Full Text (542) Reporting Checklist Peer Review File COI Form Open Access

Editorial Commentary | Biomarkers Sciences

The quest for the optimal biomarker: is extending the spectrum of targeted PIK3CA mutations in breast cancer carcinoma worthwhile?

Stanislas Quesada, William Jacot

Annals of Translational Medicine

2023;

(11)

:393

| https://dx.doi.org/10.21037/atm-23-1608

(October 2023)

PDF Pages: 393 Full Text (328) Peer Review File COI Form Open Access

Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer

Zaryab Gul, Maged Henary

Annals of Translational Medicine

2023;

(11)

:394

| https://dx.doi.org/10.21037/atm-23-467

(October 2023)

PDF Pages: 394 Full Text (269) COI Form Open Access

Editorial Commentary | Clinical Studies

Mortality reduction in severe community-acquired pneumonia: key findings from a large randomized controlled trial and their clinical implications

Ovidiu Vornicu, Emily Perriens, Sydney Blackman, Elina Smoos, Christophe Al Sammour, Ilann Oueslati, Alexis Philippot, David Vidal Bankier, Charbel Haddad, Maha Bendoumou, Tom François, Isabelle Michaux, Anne-Sophie Dincq, Patrick Evrard, Pierre Bulpa, Patrick M. Honore

Annals of Translational Medicine

2023;

(11)

:395

| https://dx.doi.org/10.21037/atm-23-1719

(October 2023)

PDF Pages: 395 Full Text (557) COI Form Open Access

Is radiotherapy after primary chemotherapy (RAPCHEM) on the right path to de-escalation?

Joanna Socha, Elżbieta Senkus

Annals of Translational Medicine

2023;

(11)

:396

| https://dx.doi.org/10.21037/atm-23-549

(October 2023)

PDF Pages: 396 Full Text (309) COI Form Open Access

Editorial Commentary | Data Sciences

A machine learning-based algorithm to eliminate breast and axillary surgery in patients with breast cancer and pathological complete response after neoadjuvant chemotherapy

Alexandre de Nonneville, Laurys Boudin, Gilles Houvenaeghel, Anthony Gonçalves, François Bertucci

Annals of Translational Medicine

2023;

(11)

:397

| https://dx.doi.org/10.21037/atm-23-689

(October 2023)

PDF Pages: 397 Full Text (259) COI Form Open Access

Editorial Commentary | Emerging Therapeutics

Preclinical and clinical efficacy of trastuzumab-deruxtecan in breast cancer brain metastases: a new insight on central nervous system activity

Marta Vaz Batista, José Perez-Garcia, Inês Eiriz, Maria Gion, Antonio Llombart, Sofia Braga, Javier Cortés

Annals of Translational Medicine

2023;

(11)

:398

| https://dx.doi.org/10.21037/atm-23-1603

(October 2023)

PDF Pages: 398 Full Text (390) COI Form Open Access

Treatment of endocrine resistant metastatic breast cancer in the era of antibody drug conjugates

Natalie K. Heater, Stephanie Franco, Ami Shah

Annals of Translational Medicine

2023;

(11)

:399

| https://dx.doi.org/10.21037/atm-23-314

(October 2023)

PDF Pages: 399 Full Text (287) COI Form Open Access

Letter to the Editor | Clinical Studies

Challenges of non-mass enhancement breast lesions mimicking malignancy encountered on breast magnetic resonance imaging

Eun Jung Choi

Annals of Translational Medicine

2023;

(11)

:400

| https://dx.doi.org/10.21037/atm-23-1787

(October 2023)

PDF Pages: 400 Full Text (257) COI Form Open Access

Erratum

Erratum to the important roles and molecular mechanisms of annexin A₂ autoantibody in children with nephrotic syndrome

Editorial Office

Annals of Translational Medicine

2023;

(11)

:401

| https://dx.doi.org/10.21037/atm-2023-20

(October 2023)

PDF Pages: 401 Full Text (218) Open Access

Erratum to liposomal honokiol inhibits glioblastoma growth through regulating macrophage polarization

Editorial Office

Annals of Translational Medicine

2023;

(11)

:402

| https://dx.doi.org/10.21037/atm-2023-18

(October 2023)

PDF Pages: 402 Full Text (249) Open Access

Erratum to abnormal neutrophil polarization in chronic obstructive pulmonary disease and how cigarette smoke extracts attract neutrophils

Editorial Office

Annals of Translational Medicine

2023;

(11)

:403

| https://dx.doi.org/10.21037/atm-2023-16

(October 2023)

PDF Pages: 403 Full Text (263) Open Access

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report | Clinical Studies

Cardiac arrest due to an unexpected inability to ventilate in a tracheostomy patient suggesting the need for a routine anesthesia checklist and an anesthesia relevant emergency pathway for tracheostomy management: a case report

Mario Villasenor, Jeremy Bengson, Benjamin H. Cloyd, Tobias Eckle

Published online: 08 December 2023

Review Article | Data-Driven Clinical Practice and Policy Making

The role of reconstructive microsurgeons in liver transplantation—a narrative review

Min Kai Chang, Andre Eu Jin Cheah

Published online: 07 December 2023

Editorial

The Integral Theory—paradigm, not hypothesis

Darren M. Gold

Published online: 06 December 2023

Original Article

Quality of life with minimally invasive repair of pectus excavatum: a systematic review and meta-analysis

Jameelah Sheik Mohamed, Jian Wei Tan, John Kit Chung Tam

Published online: 06 December 2023

Review Article | Emerging Medical Technology Innovation and Translation

ProtekDuo percutaneous ventricular support system—physiology and clinical applications

Kevin John John, Christoph G. S. Nabzdyk, Haval Chweich, Ajay Kumar Mishra, Amos Lal

Published online: 04 December 2023

Review Article | Data-Driven Clinical Practice and Policy Making

The role of everolimus in metastatic breast cancer and possibilities of moving forward—a narrative review

Gabor Rubovszky

Published online: 04 December 2023

Review Article | Basic and Mechanism Sciences

A systematic review of preclinical studies evaluating the association between nicotine and the initiation and progression of cancer

Mimi M. Kim, Isabella Steffensen, Red Thaddeus D. Miguel, Tanja Babic, Aubrey D. Johnson, Ryan Potts, Christopher S. Junker

Published online: 01 December 2023

Review Article | Emerging Therapeutics

Potential role of short-chain fatty acids in the pathogenesis and management of acute lymphocytic leukemia

Yajing Song, Peter Gyarmati

Published online: 30 November 2023

Original Article

Ophthalmic artery reversal predicts contralateral body weakness symptoms better than carotid Doppler velocity—preliminary results

Anne E. Moore, Laligam N. Sekhar, Kirk W. Beach

Published online: 27 November 2023

Retraction

Retraction: gambogic acid affects high glucose-induced apoptosis and inflammation of retinal endothelial cells through the NOX4/ NLRP3 pathway

Xiaojing Ye, Feng Xiang, Yiyi Hu

Published online: 27 November 2023

Editorial Commentary | Clinical Studies

Viscous fiber from oats and barley: keep them in your cholesterol-lowering portfolio

Liana L. Guarneiri, Carol F. Kirkpatrick, Kevin C. Maki

Published online: 17 November 2023

Review Article

A systematic review of the complications of skin puncturing procedures in the upper limbs of patients that have undergone procedures on the axilla or breast

Michael Hadjistyllis, Akshay Soni, David J. Hunter-Smith, Warren M. Rozen

Published online: 17 November 2023

Review Article

Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions

Yanis Berkane, Haizam Oubari, Loïc van Dieren, Laura Charlès, Elise Lupon, Michelle McCarthy, Curtis L. Cetrulo Jr, Nicolas Bertheuil, Basak E. Uygun, David M. Smadja, Alexandre G. Lellouch

Published online: 15 November 2023

Review Article

Narrative review on the evolving role of HER2/neu targeting in uterine serous cancers

Aarthi S. Jayraj, Salamatu Abdul-Aziz, Anisa Mburu, Avinash Upadhyay, Nilanchali Singh, Prafull Ghatage

Published online: 09 November 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Surgical delay in abdominal based flap surgery: a scoping review

Warren M. Rozen, Vikash Yogaraj, Mustafa Siddiqui, Evania Lok, David J. Hunter-Smith

Published online: 06 November 2023

Editorial | Emerging Therapeutics

Vagus nerve stimulation in postoperative thoracic surgery: the obstacle is the path

Stefanos Zafeiropoulos

Published online: 30 October 2023

Editorial Commentary | Data-Driven Clinical Practice and Policy Making

Liquid biopsy to tailor the treatment of advanced hormone receptor-positive breast cancer in the era of novel endocrine agents and CDK4/6-inhibitors

Elia Seguí, Francesco Schettini

Published online: 28 October 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Cosmetic male genital surgery: a narrative review

Michel Alain Danino, Pierre Trouilloud, Mehdi Benkhadra, Arthur Danino, Romain Laurent

Published online: 26 October 2023

Original Article

Manufacture and evaluation of nano-silver-poly-DL-lactide-co-caprolactone-small intestinal submucosa biological mesh in abdominal wall reconstruction

Li Zhu, Hui Li, Yizhu Chen, Yongjing Dai, Xiru Li

Published online: 26 October 2023

Expert Consensus | Data-Driven Clinical Decision Making and Policy Making

Anti(angiogenic) food components: can be a major source of bias in the investigation of angiogenesis inhibitors

Reza Rastmanesh, Abdalla Bowirrat, Ashim Gupta, Elizabeth Gilley, Kenneth Blum

Published online: 23 October 2023

Editorial Commentary

Is obstructive sleep apnea a risk factor for lung cancer?—from pathophysiological mechanisms to clinical data

Miguel Ángel Martínez-García, Grace Oscullo, Jose Daniel Gómez-Olivas, Marina Inglés-Azorin, Sergio Mompeán

Published online: 20 October 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Surgical management of breast cancer-related lymphedema: a narrative review of contemporary practices

Pedro Ciudad, Joseph M. Escandón, Daniela Duarte-Bateman, Lauren Escandón, Michele Maruccia, Antonio J. Forte, Horacio F. Mayer, Oscar J. Manrique

Published online: 16 October 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Breast reconstruction after mastectomy in patients with obesity: a narrative review

Priscila Cevallos, Charlotte Berry, Kelsey Jordan Lipman, Carrie A. Kubiak, Anita T. Mohan, Haripriya S. Ayyala, Oscar J. Manrique, Rahim Nazerali

Published online: 20 September 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Revisiting the reconstructive ladder for soft tissue reconstruction in the lower extremity

Shubashri Jeyaratnam, Sandeep Jacob Sebastin, Soumen Das De

Published online: 11 September 2023

Editorial | Data-Driven Clinical Practice and Policy Making

Subsolid pulmonary nodules: why not “watch and wait”?

Sara Fra-Fernández, Luis Gorospe-Sarasúa, Alberto Cabañero-Sánchez, Gemma Muñoz-Molina, Usue Caballero-Silva, Nicolás Moreno-Mata

Published online: 11 September 2023

Editorial

Preface on highlights in anesthesia and critical care medicine

Tobias Eckle, Benjamin Scott

Published online: 07 September 2023

Editorial | Omics Sciences

Gut microbiota alterations in acute myocardial infarction: (diabetic) context is everything

Anastasios Lymperopoulos

Published online: 05 September 2023

Editorial Commentary | Clinical Studies

Include oats, barley and soluble fibre in your diet: an achievable goal to improve cardiometabolic health

Sally D. Poppitt, Jennifer L. Miles-Chan

Published online: 04 September 2023

Editorial | Clinical Studies

The retinal ganglion cells in metabolic syndrome

Konstantinos Pappelis, Irini Chatziralli, Odysseas Georgiadis, George P. Theodossiadis, Panagiotis G. Theodossiadis, Nomdo M. Jansonius

Published online: 04 September 2023

Editorial | Omics Sciences

Morbidity and mortality in Schaaf-Yang syndrome

Johann Georg Maaß, Heiko Brennenstuhl, Christian Patrick Schaaf

Published online: 28 August 2023

Review Article | Data-Driven Clinical Practice and Policy Making

A systematic review of capsule aspiration in capsule endoscopy

Camilla Thorndal, Ola Selnes, Ian Io Lei, Anastasios Koulaouzidis

Published online: 28 August 2023

Editorial Commentary

Research reporting guidelines for cell lines: more than just a recommendation

Ralf Weiskirchen

Published online: 21 August 2023

Editorial Commentary | Emerging Medical Technology Innovation and Translation

Non-invasive functional MRI techniques for early detection of kidney injury in chronic kidney disease: a positive step forward

Sylvain Bodard, Francois H. Cornelis

Published online: 16 August 2023

Review Article | Emerging Therapeutics

Review on endobronchial therapies—current status and future

Joyce W. Y. Chan, Ivan C. H. Siu, Aliss T. C. Chang, Molly S. C. Li, Rainbow W. H. Lau, Tony S. K. Mok, Calvin S. H. Ng

Published online: 11 August 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Moving the needle: a narrative review of enhanced recovery protocols in breast reconstruction

Robert Craig Clark, Alexandra Alving-Trinh, Miriam Becker, Garrison A. Leach, Amanda Gosman, Chris M. Reid

Published online: 24 July 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Point-of-care ultrasound use in COVID-19: a narrative review

Mui Teng Chua, Yuru Boon, Chew Kiat Yeoh, Zisheng Li, Carmen Jia Man Goh, Win Sen Kuan

Published online: 13 July 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Management of complications following implant-based breast reconstruction: a narrative review

Dean H. Meshkin, Joseph M. Firriolo, Nolan S. Karp, Ara A. Salibian

Published online: 12 July 2023

Review Article | Data-Driven Clinical Practice and Policy Making

An evaluation of the total ankle replacement in the modern era: a narrative review

Isabel Shaffrey, Jensen Henry, Constantine Demetracopoulos

Published online: 12 July 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Demystifying vascularized lymph node transfers and lymphatico-venous anastomoses

Yasser Almadani, Peter Davison, Johnny Ionut Efanov, George Kokosis, Joshua Vorstenbosch

Published online: 10 July 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Narrative review of patient-reported outcomes of breast reconstruction

Eric I. Chang

Published online: 03 July 2023

Review Article | Emerging Therapeutics

Innervated breast reconstruction: a narrative review of neurotization techniques and outcomes

Joseph M. Escandón, Jessica Mroueh, Christopher M. Reid, Devinder Singh, Keith Sweitzer, Pedro Ciudad, Rahim Nazerali, Antonio J. Forte, Oscar J. Manrique

Published online: 27 June 2023

Review Article | Emerging Therapeutics

Twenty-five years with HER2 targeted therapy

Jan Trøst Jørgensen

Published online: 25 June 2023

Review Article | Data-Driven Clinical Practice and Policy Making

Technical consideration for breast reconstruction in patients requiring neoadjuvant or adjuvant radiotherapy: a narrative review

Karla C. Maita, Ricardo A. Torres-Guzman, Francisco R. Avila, John P. Garcia, Brian D. Rinker, Olivia A. Ho, Antonio J. Forte

Published online: 20 June 2023

Review Article

Prepectoral versus subpectoral two-stage implant-based breast reconstruction: U.S. medical center experience and narrative review

Joseph M. Escandón, Anna Weiss, Jose G. Christiano, Howard N. Langstein, Lauren Escandón, Peter A. Prieto, Jessica C. Gooch, Oscar J. Manrique

Published online: 20 June 2023

Editorial Commentary | Emerging Therapeutics

Daily oral ibandronate with adjuvant endocrine therapy in postmenopausal women with estrogen receptor-positive breast cancer: editorial commentary

Robert Coleman

Published online: 17 March 2023

Editorial Commentary

More on treatment de-escalation, biomarkers of response in human epidermal growth factor receptor 2 (HER2)-positive breast cancer: long-term outcomes and translational research findings of the PREDIX HER2 trial

Max S. Mano

Published online: 03 March 2023

Editorial Commentary | Emerging Therapeutics

COSMIC-312, a disappointing result—is that so surprising?

Xavier Adhoute, Marc Bourlière, Rodolphe Anty

Published online: 02 March 2023

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.