The worst of both worlds-combined pulmonary fibrosis and emphysema syndrome

Rarely, we will see patient in our practice who might appear to have a combination of two different disease belonging to opposing ends of a spectrum of clinical features. Combined pulmonary fibrosis and emphysema syndrome (CPFE) is one of such rare conditions where the physician encounters a mix of clinical features which are thought to be inconsonant. These patients have a variable mix of pulmonary fibrosis and emphysema and a very different course compared to patients with either disease alone.