Erratum to PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production

Erratum to: Ann Transl Med 2020;8:126

The article (1) titled “PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production” (doi: 10.21037/atm.2020.02.37), unfortunately contains errors in Figure 1B. The images of Western blotting analysis of PITPNC1 and β-actin were mistakenly used. Notably, the correction does not affect the conclusion of our paper.

Figure 1B in the original article:

The updated version of Figure 1, containing the correct data for Western blotting analysis of PITPNC1 and β-actin in Figure 1B, is shown below.

Figure 1 High expression of PITPNC1 in radioresistant rectal cancer tissue. (A) Heatmap of Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip data of rectal cancer tissue derived from 11 patients in GSE56699. (B) Western blotting analysis of PITPNC1 level in colorectal cancer tissue from patients who manifested radioresistance and those who did not. β-actin was used as a loading control. (C) Quantization of western blotting result using relative expression level of PITPNC1 compared to β-actin. (D) Immunohistochemistry results in the comparison of the expression level of PITPNC1 in radioresistant colorectal cancer tissue and radiosensitive tissue. Representative photographs of the two groups are shown. R, resistant; S, sensitive; RES, resistant; CR, complete remission; PITPNC1, phosphatidylinositol transfer protein, cytoplasmic 1.

The authors confirmed this error did not significantly affect either the results or the conclusions of the paper.

Click here to view the updated version of the article.

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References

1. Tan Y, Shao R, Li J, et al. PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production. Ann Transl Med 2020;8:126. [Crossref] [PubMed]