Erratum to butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis

Erratum to: Ann Transl Med 2021;9:873.

This article (1) titled “Butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis” (doi: 10.21037/atm-21-2158), unfortunately contains an error in Figure 3. Specifically, the transmission electron microscopy images labeled as belonging to the LPS group in Figure 3I were mistakenly used in place of images from the alcohol group. This error occurred due to an oversight in the placement of the images. The correction of this information does not affect the results and conclusions of this paper. The corrected image of Figure 3 is provided below.

Figure 3 in the original article:

The correct version of Figure 3 is presented below.

Figure 3 Butyrate failed to directly inhibit gasdermin D (GSDMD)-mediated pyroptosis in LO2 cells. (A-D) MTT evaluation of lipopolysaccharide (LPS), butyrate, alcohol, alcohol or LPS with or without butyrate on the proliferation of LO2 cells (n=6 per group). (E,F) Cleaved GSDMD protein expression was detected by western blot (n=3 per group). (G,H) Expression levels of NLRP3, cleaved GSDMD, mature caspase-1, and IL-1β were detected by western blot (n=3 per group). (I) Transmission electron microscopy showed ultrastructural changes of pyroptosis in LO2 cells. Normal mitochondria (N), Cellular swelling (C). Normal control (NC), Alcohol (Alc), Alcohol + Butyrate (Alcohol + But), Butyrate (But). *, P<0.05; **, P<0.01 compared with NC group; ^#, P<0.05; ^##, P<0.01 compared with alcohol or LPS group.

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References

1. Zhang T, Li J, Liu CP, et al. Butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis. Ann Transl Med 2021;9:873. [Crossref] [PubMed]