Special issue: “MET as actionable target in cancer therapy”

MET (c-Met, or c-MET) receptor is a multifunctional receptor tyrosine kinase that has been known for many years of its pivotal role in human developmental and cancer signaling. The natural ligand for MET is hepatocyte growth factor [HGF; also called scatter factor (SF)], which can act in autocrine, endocrine or paracrine fashion on the MET-expressing epithelial cells (1).