Inhibition of SOX9 may be an effective target for increasing radiosensitivity in gastrointestinal cancer

Radiotherapy (RT) plays an important role in the treatment of gastrointestinal (GI) cancer. When combined with other anti-cancer therapy modalities, RT can increase cytotoxicity and improve treatment efficacy. However, some patients develop radioresistance and show treatment failure. In addition, certain patients experience acute enteritis during abdominal RT for GI cancer or sequelae of chronic radiation enteritis after RT. Therefore, it is important to determine the mechanism of radioresistance as well as RT-induced enteritis